What Is Spermidine?

Roughly 10 years ago, a research team at the University of Graz in Austria discovered spermidine’s ability to trigger autophagy. Spermine is a naturally occuring polyamine that occurs in all eukaryotes, but is rare in prokaryotes. It is essential for cell growth in both normal and neoplastic tissue.

Polyamines can bind to many different types of molecules making them very useful. They support processes, including cell growth, DNA stability, cell proliferation, and apoptosis. It also appears that polyamines function in a similar way to growth factors during cell division. This is why putrescine and spermidine are important for healthy tissue growth and function.

Spermidine and putrescine are known to stimulate autophagy. A system that breaks down waste inside cells and recycles cellular components. It is an important quality control mechanism for the mitochondria, the powerhouses of our cells. Autophagy allows damaged or defective mitochondria to be broken down and disposed of. The disposal of mitochondria is more tightly controlled than was before believed.

How Does Spermidine Work On Our Body?

Spermidine plays an essential role in organisms, like humans and even plants. One of spermidine's biggest and most profound functions, from which other functions stem from, is the ability to counteract aging and promote autophagy.

Our bodies are made up of cells. As we age, our cells age as well. When these cells become old or damaged, it can cause build up of dead or toxic organelle matter in our bodies, potentially leading to age-related disease and injury. Spermidine in our cells optimizes autophagy and cellular renewal.

Spermidine is also known to regulate various cellular processes including:
♦ DNA Stability
♦ Cellular growth
♦ Cellular differentiation
♦ Apoptosis (Which is cellular death as a normal part of growth and development in organisms)

When you hear that autophagy is basically cells cannibalizing one another, it’s easy to think that it sounds harmful to your body. However, autophagy is quite beneficial and something scientists believe you should be striving for on a regular basis. While it’s still unclear how exactly autophagy creates some of these benefits, here are some benefits of autophagy:
♦ Removing toxic proteins from the cells that may be a cause of some age-related diseases
♦ Recycling residual proteins
♦ Providing energy and building blocks for cells
♦ Promoting regeneration and healthy cells

Other Potential Health Benefits

❶ Improves Cardiovascular Health

Cardiovascular diseases include strokes, vascular death, heart attacks, and acute coronary artery disease. The occurrence of any of these conditions is higher in people who have high blood pressure. Taking Spermidine supplements will lower high blood pressure and prevent these diseases. Spermidine also prevents the death of heart cells, which can result in a heart attack.

❷ Enhances Brain Health

Brain functions such as thinking, planning, perception, and understanding language suffer as one gets older. Age can also result in memory problems that affect the quality of your life. Taking Spermidine supplements will improve your brain health and help preserve brain function.

❸ Prevents Cancer

Spermidine regulates cell growth, number, and death, which can help prevent cancer and tumors. It also protects your cell DNA from free radical attacks, which can cause cancer. When you take Spermidine supplements made with Spermidine-rich wheat germ extract, you will go a long way in protecting your body from cancer. You can use Spermidine supplements during cancer treatment.

❹ Prevents Aging

Spermidine helps fight age-related diseases such as heart attacks and inflammation-related conditions. It increases longevity, enhances stress-resistance, and preserves your locomotion abilities. When taking these supplements, you are less likely to experience joint, and muscle aches or have heart-related problems.

❺ Promotes Hair Growth

A full head of hair is both beautiful and a sign of youth. Spermidine-rich wheat germ extract supplements will promote hair growth.

❻ Enhances cell Growth

People with enhanced cell growth are healthy, and their bodies heal faster. Spermidine helps enhance cell growth and repairs damaged cells. If you are going through radiation therapy due to cancer, taking Spermidine powder will help repair your cells and make you healthier.

Spermidine Side Effects

There are no known adverse side effects from spermidine powder or supplements. There have been a number of studies conducted with it, and the results suggest that it is well tolerated. Of course, as with any supplement, if you do experience side effects, cease taking it immediately and consult your doctor.

Where To Buy Spermidine Powder And Other Spermidine Products?

Many foods contain spermidine. These include grapefruit, mature cheese, mushrooms, soy products, legumes, corn, and whole grain. Chickpeas, peas, green peppers, broccoli, oranges, green tea, and rice bran contain it too. Note that much of the Mediterranean diet contains spermidine rich foods. But it is struggle to get enough spermidine in our diet. So, taking spermidine powder or supplements will be good choice to get enough spermidine.

API CDMO is a professional manufacturer and supplier of Spermidine in China, offering raw ingredients fur bulk sale:
① Spermidine powder CAS: 124-20-9
② Spermidine trihydrochloride powder CAS: 334-50-9
③ Wheat Germ Extrac powder(1%) CAS: 124-20-9

We also accept the custimized service for pharmaceutical intermediates in our lab.If you want to buy spermidine powder in large quantities, please send an inquiry to us directly. Documents like COA or other related documents will be sent upon your inquiry email.


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[2] Yue, F., Li, W., Zou, J., Jiang, X., Xu, G., Huang, H., & Liu, L. (2017). Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy. Cancer Research, canres-3462.
[3] Landau, G., Bercovich, Z., Park, M. H., & Kahana, C. (2010). The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. Journal of Biological Chemistry, 285(17), 12474-12481.
[4] Choi, Y. H., & Park, H. Y. (2012). Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells. Journal of biomedical science, 19(1), 31
[5] Minois, N., Carmona-Gutierrez, D., & Madeo, F. (2011). Polyamines in aging and disease. Aging (Albany NY), 3(8), 716-732.
[6] Karkas, JD; Margulies, L; Chargaff, E (1975). "A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties". The Journal of Biological Chemistry. 250 (22): 8657–63. PMID 241752.
[7] Schroeder, S., Hofer, S.J., Zimmermann, A., Pechlaner, R., Dammbrueck, C., … & Madeo, F. (2021). Dietary spermidine improves cognitive function. Cell Reports, 35(2), 108985. https://doi.org/10.1016/j.celrep.2021.108985
[8] Hu, J; Mahmoud, MI; El-Fakahany, EE (1994). "Polyamines inhibit nitric oxide synthase in rat cerebellum". Neuroscience Letters. 175 (1–2): 41–5.

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