Urolithins Description
Urolithins are secondary metabolites of ellagic acid derived from ellagitannins. In humans ellagitannins are converted by the gut microflora into ellagic acid which is further transformed into urolithins A, urolithin B, urolithin C and urolithin D in the large intestines.Urolithin A (CAS:1143-70-0) is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria.It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones.
Urolithin B (CAS:1139-83-9) is the last product after all the other urolithin derivatives are catabolized. Urolithin B is found in urine as urolithin B glucuronide.
8-O-Methylurolithin A(Urolithin A 8-Methyl Ether)-CAS:35233-17-1 is the intermediate product during the synthesis of Urolithin A.
Urolithins Function
♦ Anti-inflammatory, anti-oxidant, anti-cancer, hypoglycemic and other biological activities.♦ Urolithins can improve the quality and function of mitochondria, and improve the strength and endurance of aging muscles.
♦ Urolithins has been proven to restart mitochondrial autophagy and reverse muscle aging.
Urolithins Application
Urolithin is a natural product with antiproliferative and antioxidant activity. Urolithin is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin has been shown many health benefits on our body, such as extends lifespan, help prevent kinds of cancers,improve memory,prevents muscle loss...it also has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.Because of its many benefits, this product has been widely used in various fields, among which the three most typical fields:❶ Sports nutrition
❷ Dietary supplements
❸ Cosmetics
Urolithins Side Effects
No adverse effects have been reported yet. Urolithin A, Urolithin B and 8-O-Methylurolithin A are generally regarded as safe (GRAS) by the FDA and has no known side-effects to date. More clinical trials on Urolithins product should be done in the future for a more thorough evaluation of safety parameters that are not currently available due to a lack of studies being conducted at this time.Urolithin A(UA) VS Urolithin B(UB)
Both Urolithin B and Urolithin A powder are used in supplements, but with different functional benefits. They work with a different mechanism of action. Urolithin A is mainly for the Anti-aging formula for its mitophagy mechanism while urolithin B is in sports nutrition formula as a muscle-building ingredient.Urolithin A is a much more well-researched compound, it has been generally regarded as safe (GRAS) by the FDA, while urolithin B is not. There are more supplement brands using urolithin A than urolithin B. Urolithin A and Urolithin B are closed related. Pomegranate extract contains both of these urolithins. Pomegranates are the zenith of fruit. After digestion, their constituent parts can be converted by gut flora into urolithin C and then further transformed into Urolithin D and A, and then Urolithin B. In this sense, urolithin A can be converted to urolithin B.
Consequently, small amounts of urolithin B can be found in the blood of individuals fed with pomegranate extract; however, its antioxidant and anti-inflammatory properties are much weaker than urolithins A. However, urolithin B has its own advantage over urolithin A. It’s able to increase muscle cell size and accelerate muscle growth.
Where To Buy Bulk Urolithin A & Urolithin B & 8-O-Methylurolithin A Powder?
APICDMO is the leading manufacturer and supplier of Urolithins, has own lab for custom service and own factory for large production Urolithin powders. Pure urolithin A powder,bulk urolithin B powder and pure 8-O-Methylurolithin A powder are all available. If you want to buy top quality Urolithins powder with purity up to 99%, please don’t hesitate to contact with us immediately. Technical documents and related testing reports can be provided at the first time.Reference
[1] Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer.Totiger et al. Mol.Cancer Ther., 2019;18:301[2] D. Ryu, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med., 22 (2016), pp. 879-888.
[3] C. Ploumi, et al. Mitochondrial biogenesis and clearance: a balancing act FEBS J., 284 (2017), pp. 183-195.
[4] P.A. Andreux, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans Nat. Metab., 1 (2019), pp. 595-603.
[5] D. Taube, et al. Fractalkine depresses cardiomyocyte contractility PLoS ONE, 8 (2013), Article e69832.
[6] Urolithin A inhibits the catabolic effect of TNFα on nucleus pulposus cell and alleviates intervertebral disc degeneration in vivo. Front. Pharmacol., 9 (2018), p. 1043.
[7] A. Diot, et al. Mitophagy plays a central role in mitochondrial ageing Mamm. Genome, 27 (2016), pp. 381-395.
[8] Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. Yuan et al. ACS Chem.Neurosci., 2016;7:26.
[9] [8]FDA GRAS notice GRN No. 791: urolithin A". US Food and Drug Administration. 20 December 2018. Retrieved 25 August 2020.