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3-Amino-5-methylisoxazole
3-Amino-5-methylisoxazole is the major intermediate formed during sulfamethoxazole biodegradation by Pseudomonas psychrophila strain HA-4. It is the intermediate formed during the photocatalytic degradation of sulfamethoxazole (SMX).
| Product | 3-Amino-5-methylisoxazole | ||
| CAS No. | 1072-67-9 | ||
| Synonyms | 3-Isoxazolamine,5-methyl-;
3-Methyl-5-aminoisoxazole; 5-Methyl-3-aminoisoxazole; 5-methyl-3-isoxazolamin. |
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| SMILES | Cc1cc(N)no1 | ||
| InChI | 1S/C4H6N2O/c1-3-2-4(5)6-7-3/h2H,1H3,(H2,5,6) | ||
| InChI key | FKPXGNGUVSHWQQ-UHFFFAOYSA-N | ||
| Availability | In Stock | ||
| MF. | C4H6N2O | MW. | 98.1 |
| Melting Point | 59-61 °C | Boiling Point | 183.6℃ |
| Appearance | Yellow crystalline powder | Purity | 97% |
| Application |
For research use only |
Storage | 2-8°C |
| COA & NMR | Download | MSDS | Download |
3-Amino-5-methylisoxazole Application:
3-Amino-5-methylisoxazole was used in synthesis of:
❶ Naphtho[1,2-e][1,3]oxazines
❷ Series of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones, having potential mosquito larvicidal activity
❸ Hydroxylamines of sulfadiazine and sulfamethoxazole
Reference
[1] Rapid degradation of sulphamethoxazole and the further transformation of 3-amino-5-methylisoxazole in a microbial fuel cell. Lu Wang et al. Water research, 88, 322-328 (2015-10-30)
[2] Synthesis of trans-1,3-diaryl-2-(5-methylisoxazol-3-yl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines via bismuth(III)-catalyzed one-pot pseudo-four component reaction.
Mehdi Shafiee et al. Molecular diversity, 16(4), 727-735 (2012-10-24)
[3] Contribution of biotic and abiotic factors in the natural attenuation of sulfamethoxazole: A path analysis approach. Yan Li et al. The Science of the total environment, 633, 1217-1226 (2018-05-16)
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