Ensitrelvir(S-217622) CAS:2647530-73-0
December 3, 2022
QUCHIC CAS:1400742-42-8
April 13, 2023
3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride
3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride is used as Ensitrelvir (S-217622) Intermediates. Ensitrelvir (S-217622) is an oral antiviral drug, which acts as an orally active 3C-like protease inhibitor for the treatment of COVID-19 infection. It has demonstrated antiviral effectiveness against Delta variant and the recently emerged Omicron variant. API CDMO can provide CDMO services for COVID-19 drugs with sufficient capacity, only for research use.
| Product | 3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride | ||
| CAS No. | 135206-76-7 | ||
| Synonyms | NX21851;
Ensitrelvir intermediates; 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride. |
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| SMILES | CN1N=C(CCl)N=C1.[H]Cl | ||
| InChI | 1S/C4H6ClN3.ClH/c1-8-3-6-4(2-5)7-8;/h3H,2H2,1H3;1H | ||
| InChI key | KISIDCUHOLGEPR-UHFFFAOYSA-N | ||
| MF. | C4H7Cl2N3 | MW. | 168.02 |
| Appearance | White to off-white powder | Purity | >96% |
| Application | For research use only | Storage | Store at -20°C. |
| COA & NMR | Download | MSDS | Download |
Other Ensitrelvir (S-217622) Intermediates:
6-(Ethylthio)-1-(2,4,5-trifluorobenzyl)-1,3,5-triazine-2,4(1H,3H)-dione
CAS: 2771355-74-7
6-chloro-2-methyl-2H-Indazol-5-amine
CAS: 1893125-36-4
6-(Ethylthio)-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5- trifluorophenyl)methyl]-1 ,3,5-triazine-2,4(1H,3H)-dione
CAS: 2771355-73-6
Reference
[1] Yuto Unoh, et al. Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19. bioRxiv 2022.01.26.477782.
[2] World Health Organization (2022). “International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 88”. WHO Drug Information. 36 (3): 89. hdl:10665/363551
[3] “Shionogi presents positive Ph II/III results for COVID-19 antiviral S-217622”. thepharmaletter.com. 31 January 2022.
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