SDB-005 CAS:2180934-13-6

SDB-005 is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.It is presumed to be an agonist of the CB1 and CB2 cannabinoid receptors. SDB-005 is the indazole core analog of PB-22 where the 8-hydroxyquinoline has also been replaced with a naphthalene group.

The code number SDB-005 was originally used for a different compound, the N-phenyl instead of N-benzyl analogue of SDB-006. This compound is a potent agonist of the CB1 receptor (Ki = 21 nM) and CB2 receptor (Ki = 140 nM).

CAS 2180934-13-6 Information

Product	SDB-005
CAS Number	2180934-13-6
Formula	C23H22N2O2
Molar mass	358.441 g·mol−1
PubChem CID	125181303
ChemSpider	30922481
UNII	Z6XWV5U765

However, SDB-005 was subsequently used as the name for the indazole-3-carboxylate compound mentioned above when it was sold in Europe as a designer drug, and was entered into the EMCDDA synthetic drug database under this name.Consequently, there are now two distinct, yet fairly closely related cannabinoid compounds, which may both be referred to under the code SDB-005.

Reference

[1] “SDB-005”. Cayman Chemical. Retrieved 27 June 2015.
[2] Banister SD, Wilkinson SM, Longworth M, Stuart J, Apetz N, English K, et al. (July 2013). “The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse”. ACS Chemical Neuroscience. 4 (7): 1081–92. doi:10.1021/cn400035r. PMC 3715837. PMID 23551277.
[3] EWS_EU: Neue Psychoaktive Substanzen, April 2015