Hydroxypinacolone Retinoate(HPR) Is a cosmetic grade ester of all-trans retinoic acid (Vitamin A). It binds to retinoid receptors which initialise a host of skin promoting benefits when activated. It promotes anti-aging applications with low irritation in its concentrated stable form. Studies have also evaluated this ingredient as being effective in the treatment of acne and hyperpigmentation.This ingredient increases the rate of cell turnover to reduce the appearance of wrinkles, hyper-pigmentation and acne. It also improves rough and/or dry patches to give skin an even texture and complexion.
|Appearance||Yellow powder or crystal||Purity||≥99%|
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Hydroxypinacolone Retinoate (HPR) is a form of Vitamin A – and potentially a game changer! It’s a so-called retinoic acid ester, meaning that it’s directly related to retinoic acid – the active form of Vitamin A that effects change.
Other forms of retinoids (Vitamin A) have to be converted by our metabolic machinery to do something. No conversation, no effect. This applies to Retinyl Palmitate, Retinol and Retinaldehyde. That’s not the case with HPR. It binds directly to the retinoid receptors of the skin cells to work its skincare magic.The big promise of HPR is that it’s similarly active as retinoic acid (no conversion needed) but without the irritation that comes with Retinoic Acid.
Noted: The metabolic conversion of Vitamin A: retinyl palmitate –> retinol — > retinaldehyde –> all-trans-retinoic aci
Hydroxypinacolone Retinoate(HPR) is a revolutionary new form of Vitamin A – an ester of retinoic acid. HPR is bioavailable in its current state, but comes without irritation (like Retin-A) or metabolic steps (like retinol).
There are two categories of aging: intrinsic (chronological) and extrinsic (photoaging).
Extrinsic aging results from cumulative ultraviolet (UV) exposure, pollution, and lifestyle factors such as diet, exercise, sleeping positions, smoking, and daily skincare habits. It is estimated to contribute 80% to the overall visible signs of aging.
Intrinsic aging is genetically determined and controlled by one’s overall health and epigenetic factors that express inherited aging traits. Vitamin A has the ability to target both intrinsic and extrinsic aging, a major wow factor.
Now, when I say Vitamin A, what I am really referring to is retinoic acid. Any topical form of Vitamin A will come as or be converted to retinoic acid – the form used by the skin.
Retinoic Acid regulates the expression of different genes. It’s like a therapist, effectively communicating with your cells, telling them to conduct themselves in a youthful manner.
Retinoic Acid can bind to virtually any skin cell receptor and control its behavior. When Retinoic Acid does this, a cascade of events happen. An increase in epidermal cellular reproduction is initiated, the outermost layer of the skin becomes compact with new cells, new collagen and elastin fibers are produced, supporting glycosaminoglycans are deposited (such as hyaluronic acid), and new blood vessels are formed in the papillary dermis.
Retinoids are the only FDA-approved product on the market that actually reverse the signs of aging and diminish current wrinkles. Vitamin A (retinol) is used to treat skin conditions such as acne, psoriasis, aging, discoloration, and congested skin. It has supreme restorative properties and anti aging benefits. Hydroxypinacolone Retinoate also have similar effects as a cosmetic grade ester of all-trans retinoic acid (Vitamin A). HPR main effects/benefits:
♦ Promotes cellular reproduction (new cell growth)
♦ Stimulates collagen production (what makes your skin plump)
♦ Increases elastin fibers (what makes your skin snap back into place)
♦ Reduces uneven pigmentation caused by UV damage
♦ Diminishes fine lines and wrinkles
♦ Thickens skin
♦ Cleans out congested pores (bye bye blackheads!)
♦ Prevents acne
♦ Improves texture and tone of skin
♦ Promotes production of glycosaminoglycans (like hyaluronic acid)
♦ Down regulates enzymes that degrade collagen
♦ Neutralize free-radicals
♦ Makes skin look radiant
(1) Anti-Behavior Products
Promote collagen synthesis in the dermis and prevent excessive choleagen degradation. Improvements to fine lines can be seen within a week.
(2) Skin Whitening Products
Demonstrate tires, promote metabolism, and accelerate the disappearance of melanin. Literature shows that blending with VC is just as effective in treating acne scars.
(3) Acne extract products
Not only does it reduce acne, it can also reduce oil production and lighter pigeons left over from acne.
(4) Sunscreen Products
Demonstrates the enhancement of UV-induced MMP activity, protects elastin and dermal collagen, and heals wrinkles and fine lines caused by UV radiation.
(5) Repairs and Maintenance Products
Promote the synthesis of hylaluronic acid in the body, reduce skin TEWL, promote the activity of keratinocytes, increase epidermis thickness, and make the epidermis stronger.
 Truchuelo, Maria Teresa; Jiménez, Natalia; Jaén, Pedro (2014). “Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma”. Journal of Cosmetic Dermatology 13 (4): 261–268. doi:10.1111/jocd.12110.
 S. Veraldi, M. Barbareschi, E. Guanziroli; et al (2015-4). “Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres”. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 150 (2): 143–147. PMID 25876142.
 Sarah Vickery (2018年5月17日). “The Estée Lauder Companies showcases robust research at 2018 IID Meeting”. EurekAlert!. 2019年6月21。
 Katie Rodan, Kathy Fields, George Majewski, Timothy Falla (2016-12). “Skincare Bootcamp: The Evolving Role of Skincare”. Plastic and reconstructive surgery. Global open 4 (12 Suppl Anatomy and Safety in Cosmetic Medicine: Cosmetic Bootcamp): e1152. doi:10.1097/GOX.0000000000001152. PMC: 5172479. PMID 28018771
 Nora Ruth, Thomas Mammone (2018). “Antiaging effects of retinoid hydroxypinacolone retinoate on skin models”. Journal of the American Academy of Dermatology 79 (3): AB44. doi:10.1016/j.jaad.2018.05.215.
 Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres PMID 25876142; Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2015 Apr; 150(2):143-7