Imidocarb dipropionate

Imidocarb dipropionate (55750-06-6) Information

Product	Imidocarb dipropionate
CAS No.	55750-06-6
Synonyms	LABOTEST-BB LT00053575; Imidocarb dipropionate VETRANAL; N,N-bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea) dipropionate;
Availability	In Stock
MF.	C25H32N6O5	MW.	496.56
Appearance	White powder	Purity	≥99%
Application	For research use only	Storage	RT
COA & NMR	Download	MSDS	Download

 

Imidocarb dipropionate(CAS:55750-06-6)

Imidocarb dipropionate is a drug used to treat infections caused by protozoa (single-celled organisms that sometimes cause disease). For example, it is used to treat the infection babesiosis in dogs. This infection is caused by the protozoa Babesia which is transferred to pets from tick bites.

Sometimes imidocarb dipropionate is used for the treatment of ehrlichiosis in dogs, hepatozoonosis in dogs, cytaxzoonosis in cats, and babesiosis in cats. When imidocarb dipropionate is prescribed for the treatment of these diseases, it is referred to as ‘extra-label’ or ‘off label’ use. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully, as their directions may be significantly different from those on the label.

 

Imidocarb dipropionate-Mechanism of action

The mechanism of action of Imidocarb dipropionate is uncertain though two mechanisms have been proposed: interference with the production and/or utilisation of polyamines, or prevention of entry of inositol into the erythrocyte containing the parasite.

 

Imidocarb dipropionate Uses/Application/Advantages

Imidocarb dipropionate belongs to the derivative of the cephenyl, is a new animal-specific antigen icing drug, with broad spectrum, low toxicity, wide range of applications, long action time, small dose of the drug and other advantages, for livestock pear-shaped worm disease, non-pulp disease and dogs, such as red-blooded body disease not only has a good therapeutic effect, but also has a good preventive effect, for the new generation of the best anti-pear-shaped insecticidal drug, and the drug is also the only drug used in the United States. This product as a special medicine for veterinary use, with small dosage, easy to use, short course of treatment, low resistance and so on.

 

Imidocarb dipropionate Side effects

Dogs: The most common side effects in dogs include pain during the injection, salivation or drooling, nasal drip, and brief episodes of vomiting. Less commonly reported side effects of Imidocarb dipropionate include panting, diarrhea, swelling at the injection site, and restlessness. Rarely a wound can form at the injection site.

Cats: The most commonly seen side effects in cats include salivation/drooling, tearing, vomiting, diarrhea, muscle tremors, restlessness, fast heart rate, and difficulty breathing.

If the side effects of drooling or nasal drip are severe, contact your veterinarian. Treatments to reverse this may be given.

 

More Research on Imidocarb dipropionate

Imidocarb dipropionate is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites.

The pharmacodynamics of Imidocarb dipropionate were studied in various species as described by Rao et al (1980)2. The study suggests that there is a potential for adverse reactions mediated by the autonomic nervous system and especially through anticholinesterase mechanisms. Clinical experience in dogs at therapeutic dosages of less than 10 mg/kg body weight given intramuscularly or subcutaneously has established a pattern of adverse reactions. These reactions in descending order of frequency are: salivation, vomiting, and occasionally diarrhea.

 

【Reference】

• Kuttler, KL (1980). “Pharmacotherapeutics of drugs used in treatment of anaplasmosis and babesiosis”. Journal of the American Veterinary Medical Association. 176 (10 Spec No): 1103–8. PMID 7216881.
• Hashemi-Fesharki, R (1977). “Studies on imidocarb dihydrochloride in experimental Babesia ovis infection in splenectomized lambs”. The British Veterinary Journal. 133 (6): 609–14. doi:10.1016/S0007-1935(17)33941-6. PMID 608109.
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